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Selected Scientific Studies
Entegra Labs reviewed more than 185 articles to prepare the professional monograph from which Tanetin 24/7™ was created. Some of the more recent studies are listed below:

Castleman M.
The Healing Herbs: The Ultimate Guide to the Curative Power of Nature's Medicines. Emmaus, Pa: Rodale Press; 1991:173,176.

Bohlmann F, Zdero C.
Sesquiterpene lactones and other constituents from Tanacetum parthenium. Phytochemistry. 1982;21:2543,2549.

Tyler VE.
Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: Pharmaceutical Products Press; 1994:127.

De Weerdt CJ, Bootsma HPR, Hendriks H.
Herbal medicines in migraine prevention. Randomized double-blind, placebo-controlled crossover trial of a feverfew preparation. Phytomedicine. 1996;3:225,230.

Palevitch D, Earon G, Carasso R.
Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: a double-blind, placebo-controlled study. Phytother Res. 1997;11:508,511.

De Weerdt CJ, Bootsma HPR, Hendriks H.
Herbal medicines in migraine prevention. Randomized double-blind, placebo-controlled crossover trial of a feverfew preparation. Phytomedicine. 1996;3:225,230.

Newall C, Anderson LA, Phillipson JD.
Herbal Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996:120.

European Scientific Cooperative on Phytotherapy.
Tanaceti parthenii herba/folium (feverfew). Exeter UK: ESCOP; 1996. Monographs on the Medicinal Uses of Plant Drugs, Fascicule 2.

Ernst E, Pittler MH.
The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3(4A):509-514.

Maizels M, Blumenfeld A, Burchette R.
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 2004;Oct, 44(9):885-890.

Vogler BK, Pittler MH, Ernst E.
Feverfew as a preventive treatment for migraine: a systematic review. Cephalalgia 1998;18(10):704-708.

Collier HO, Butt NM, McDonald-Gibson WJ, et al.
Extract of feverfew inhibits prostaglandin biosynthesis. Lancet. 1980;2:922,923.

Sumner H, Salan U, Knight DW, et al.

Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem Pharmacol. 1992;43:2313,2320.

Williams CA, Hoult JR, Harborne JB, et al.
A biologically active lipophilic flavonol from Tanacetum parthenium.Phytochemistry. 1995;38:267,270.

Diener H, Pfaffenrath V, Schnitker J et al.
Efficacy and safety of 6.25 mg t.i.d. feverfew CO-extract (MIG-99) in migraine prevention - a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia. 2005;25:1031-41.

Ernst E, Pittler MH.
The efficacy and safety of feverfew: an update of a systematic review. Public Health Nutrition. 2000;3(4a):509-514.

Pfaffenrath V, Diener HC, Fischer M, et al.
The efficacy and safety of tanacetum parthenium in migraine prophylaxis - a double blind, multicentre, randomized placebo-controlled dose-response study. Cephalagia. 2002;22:523-532.

Skidmore-Roth L.
Mosby's handbook of herbs and natural supplements. St. Louis: Elsevier Science Imprints. 2001.

Eur J Neurol. 2004 Jul;11(7):475-7.
High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G.

Intern Med J. 2004 Jun;34(6):372-3; author reply 373. Comment on: Intern Med J. 2003 Sep-Oct;33(9-10):436-42.
High-dose riboflavin for the prevention of migraine: can we afford to ignore it? Davis JS.

Vitam Horm. 2004;69:297-312.
Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis. Bianchi A, Salomone S, Caraci F, Pizza V, Bernardini R, D'Amato CC. Department of Pharmaceutical Sciences, University of Salerno, 84084 Fisciano, Italy.

Neurology. 1998 Feb;50(2):466-70. Comment in: ACP J Club. 1998 Sep-Oct;129(2):33. Can Fam Physician. 2003 Oct;49:1291-3. Neurology. 1999 Jan 15;52(2):431-2.
Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Schoenen J, Jacquy J, Lenaerts M. Department of Neurology, University of Liege, CHR Citadelle, Belgium.

Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine
Migraine. NPRC Condition-Specific Monograph Series, 1997.

Feverfew. Lawrence Review of Natural Products, September 1994.

Awang DVC. Herbal Medicine, Feverfew.
Canadian Pharm J 1989; 122:266-70.

Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium).
Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.

Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Pharm Pharmacol 1988; 40-743-5.

Heptinstall S, White A, Williamson L, Mitchell JRA.
Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.

Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium).
Prostagland Leukotrienes Med 1982;8:653-60.

Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew.
Biochem Pharmacol 1992;43:2313-20.

Johnson ES, Kadam NP, Hylands DM, Hylands PF.
Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.

Murphy JJ. Heptinstall S, Mitchell JRA.
Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.

Altura BM. Calcium Antagonist Properties of Magnesium:
Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.

Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine.
Headache 1989; 29:590-93.

Weaver K. Magnesium and Migraine. Headache 1990; 30:168.

Faccinetti F, Sances G, Borella P, et al.
Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.

Peikert A, Wilimzig C, Kohne-Volland R.
Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.

Pfaffenrath V, Wessely P, Meyer C, et al.
Magnesium in the Prophylaxis of Migraine--A Double-Blind, Placebo-Controlled Study. Cephalalgia 1996;16:436-40.

Schoenen J, Lenaerts M, Bastings E.
High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9.

Curry EA 3rd, Murry DJ, Yoder C, et al.
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs 2004;Aug, 22(3):299-305.